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Table 2-2. Calcium channel blockers and beta-blockers used in angina.
Presc Cat contains the controlled drug
and FDA pregnancy safety category codes
Calculate dose for significantly over/underweight patient:
Toxicity: ,
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Drug Recommended Onset of
(Available as) Dose action Half-life Presc
(mg) (min) (hrs) Cat Notes
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CALCIUM CHANNEL BLOCKERS
Diltiazem
(Cardizem: 30,60,90,120 mg tabs)
30-240 Q6-8hr 30 3-4 Rx;C
Nifedipine
(Adalat,Procardia: 10,20 mg caps)
(oral) 10-30 Q6-8hr 20 4 Rx;C
(sublingual) 10 3 4 Rx;C 1
(PgDn key for more drugs)
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Drug Dose Onset(min) t� Cat Notes
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Verapamil
(Calan, Isoptin: 80,120 mg tabs;240 mg SR tabs; 5 mg/2 mL injection)
80-480 6-8 hr 30 6h Rx;C 2
BETA-BLOCKERS LABELED FOR USE IN ANGINA
Propranolol
(generic, Inderal)
oral (10,20,40,60,80,90 mg tabs)
20-80 Q6-8hr 7-14 days 3-5h Rx;C 3
slow-release (Inderal LA) (80,120,160 mg SR caps)
80-320 QD 7-14 days
Nadolol
(Corgard: 40,80,120,160 mg tabs)
40-240 QD 7-14 days 20-24h Rx;C 3
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NOTES:
1. Unlabeled use. Puncture capsule, allow to dissolve in mouth.
2. Slow-release oral form labeled for hypertension; parenteral form
labeled for use in arrhythmias.
3. "Onset" time for these agents is the estimated time to maximum
therapeutic effect.
Drug Handbook: , Antianginal Drugs