>P1;ACH3_RAT
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-3 CHAIN PRECURSOR. - RATTUS NORVEGICUS (RAT).
 M G V V L L P P P L S M L M L V L M L L P A A S A S E A E H
 R L F Q Y L F E D Y N E I I R P V A N V S H P V I I Q F E V
 S M S Q L V K V D E V N Q I M E T N L W L K Q I W N D Y K L
 K W K P S D Y Q G V E F M R V P A E K I W K P D I V L Y N N
 A D G D F Q V D D K T K A L L K Y T G E V T W I P P A I F K
 S S C K I D V T Y F P F D Y Q N C T M K F G S W S Y D K A K
 I D L V L I G S S M N L K D Y W E S G E W A I I K A P G Y K
 H E I K Y N C C E E I Y Q D I T Y S L Y I R R L P L F Y T I
 N L I I P C L L I S F L T V L V F Y L P S D C G E K V T L C
 I S V L L S L T V F L L V I T E T I P S T S L V I P L I G E
 Y L L F T M I F V T L S I V I T V F V L N V H Y R T P T T H
 T M P T W V K A V F L N L L P R V M F M T R P T S G E G D T
 P K T R T F Y G A E L S N L N C F S R A D S K S C K E G Y P
 C Q D G T C G Y C H H R R V K I S N F S A N L T R S S S S E
 S V N A V L S L S A L S P E I K E A I Q S V K Y I A E N M K
 A Q N V A K E I Q D D W K Y V A M V I D R I F L W V F I L V
 C I L G T A G L F L Q P L M A R D D T *
C;Species: RATTUS NORVEGICUS (RAT).
C;Accession: P04757
R;BOULTER J., EVANS K., GOLDMAN D., MARTIN G., TRECO D., HEINEMANN S., and PATRICK J.
NATURE 319:368-374(1986).
C;13-AUG-1987 (REL. 05, CREATED)
C;13-AUG-1987 (REL. 05, LAST SEQUENCE UPDATE)
C;01-FEB-1991 (REL. 17, LAST ANNOTATION UPDATE)
C;-!- FUNCTION: AFTER BINDING ACETYLCHOLINE, THE ACHR RESPONDS BY AN
C;EXTENSIVE CHANGE IN CONFORMATION THAT AFFECTS ALL SUBUNITS AND
C;LEADS TO OPENING OF AN ION-CONDUCTING CHANNEL ACROSS THE PLASMA
C;MEMBRANE.
C;-!- SUBUNIT: NEURONAL ACHR SEEMS TO BE COMPOSED OF TWO DIFFERENT
C;TYPE OF SUBUNITS: ALPHA AND NON-ALPHA (BETA).
C;EMBL; X03440; RNACHRAR.
C;PIR; A24572; A24572.
C;PROSITE; PS00236; NEUROTR_ION_CHANNEL.
C;SIGNAL 1 25 POTENTIAL.
C;CHAIN 26 499 ACETYLCHOLINE RECEPTOR PROTEIN, ALPHA-3.
C;DOMAIN 26 234 EXTRACELLULAR.
C;TRANSMEM 235 259
C;TRANSMEM 267 285
C;TRANSMEM 301 322
C;DOMAIN 323 471 CYTOPLASMIC.
C;TRANSMEM 472 491
C;DISULFID 153 167 BY SIMILARITY.
C;DISULFID 217 218 ASSOCIATED WITH RECEPTOR ACTIVATION
C;(BY SIMILARITY).
C;CARBOHYD 49 49 POTENTIAL.
C;CARBOHYD 166 166 PROBABLE.
C;Keywords: RECEPTOR; POSTSYNAPTIC MEMBRANE; IONIC CHANNEL; GLYCOPROTEIN; SIGNAL; TRANSMEMBRANE; MULTIGENE FAMILY.